Vitamin B5 (Pentathenic acid/Antichick dermititis factor)
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| Structure Of Vit B5 |
- Pentathenic acid (PA)
- Water soluble
- Common name:Anti chickdermititis factor
RDA:
- 5-7 mg/day
Sources:
- Major in meat, green vege, nuts, egg, grains, widely distributed in food sources
Function:
- It forms Accetylene CoA, melonyl CoA, succinyle CoA in form od Co Enzyme A
- Accetylene CoA takes part in TCA
- It form accetylecoline
- It involve in acetylation reaction
- Metonyl CoA takes part of elongation of fatty acid
- It takes part in formation of ketone bodies (accetoaccetic acid, β-hydroxy butyrate, acetone)form by breakdown of f.A Enzyme is HMG (HydroxymethyleGlutyle) CoA
- It takes part in symthesis of cholesterol (Accetyle CoA + Accetoaccetlye CoA) enzyme is HMG CoA symthesis
Succinyl CoA:
- It is found in TCA
- It takes part in Heme Synthesis (Reign Structure of CoA) succinyl CoA + glycine ΔALA (precourses for heme Synthesis)
- Î’-oxidation in the form of (accyle CoA Co enzyme A)
- Biosynthesis of Fatty acid:
- A protein, (Accyle carrier protein ACP) which involve in synthesis of Fatty Acid Vitamin B5 is constituent of ACP.
- Vitamin B5 is required for adrenocortical activity (in adrenal cortex steroids in form – which is two types. Steroids are hormones, which is responsible for many function in body + sex hormones formation)
Defficiency:
- Most of sign and symptoms Is similar to othes vitamins
- Paresthesia (B3) (abnormal sensation anytype0
- Greying of hair
- Anemia
- Mylene sheath degeneration
- Burning feet syndrome
- e.g mostly fuel in diabetis
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| Paresthesia |
Uses:
- In multi Vitamins, Vitamn B5 Is present
- To reduce morning stiffness, it is treated b Vitamin B5 as Pentothenol
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